On the basis of the 1∶250,000 scale ETM+ image of Amdo sheet in Tibet, by means of geometric calibration and mosaic process, bands 7, 4 and 3 were chosen to achieve false color composition and panchromatic band fusion, aiming at establishing the remote sensing (RS) ETM+ images at a 1∶250,000 scale in the study area. The image characteristics of various geological units together with our field investigation were utilized to adequately identify the vital interpreting symbols. Accordingly, the primary visual interpretations to major sediments,geomorphology, water system, neotectonic features were carried out and the 1∶250,000 Quaternary RS interpretation map was obtained. By combined analysis of field geological investigation, the genetic type and distribution of Quaternary sediments, geomorphologic characteristics and zoning, neotectonic movement were discussed respectively. Our results indicate that there was a spacious distribution of fluvioglacial deposit, moraine deposit(Qp3gl+fgl) and alluvial-proluvial deposits (Qp3pl +alp)of Late Pleistocene. In target region, some large-scale glacial valleys ranging from Middle to Late Pleistocene were widely developed. With the aid of linear images, water system as well as the excursion of the pluvial fan, some typical neotectonic features were initially recognized. Our study demonstrates that the RS technique is efficient in Quaternary geological investigation of Plateau region, thus inevitably providing useful information for our further study of uplift of Tibetan Plateau and environmental evolution.